{"id":93610,"date":"2021-03-16T06:07:26","date_gmt":"2021-03-16T11:07:26","guid":{"rendered":"https:\/\/PERSIAN-HERITAGE.COM\/?p=93610"},"modified":"2021-03-16T06:07:26","modified_gmt":"2021-03-16T11:07:26","slug":"survivors-struggle-as-scientists-race-to-solve-covid-mystery","status":"publish","type":"post","link":"https:\/\/PERSIAN-HERITAGE.COM\/en\/2021\/03\/16\/survivors-struggle-as-scientists-race-to-solve-covid-mystery\/","title":{"rendered":"Survivors Struggle as Scientists Race to Solve COVID Mystery"},"content":{"rendered":"
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\"\"VOA \u2014 There was no reason to celebrate on Rachel Van Lear\u2019s anniversary. The same day a global pandemic was declared, she developed symptoms of COVID-19. A year later, she is still waiting for them to disappear. And for experts to come up with some answers.<\/p>\n

The Texas woman is one of thousands of self-described long-haulers, patients with symptoms that linger or develop\u00a0out of the blue\u00a0months after they first became infected with coronavirus. Hers first arrived March 11, 2020.<\/p>\n

The\u00a0condition\u00a0affects an uncertain number of survivors in a baffling variety of ways.<\/p>\n

\u201cWe\u2019re faced with a mystery,\u201d said Dr. Francis Collins, chief of the National Institutes of Health.<\/p>\n

Is it a condition unique to COVID-19, or just a variation of the syndrome that can occur after other infections? How many people are affected, and how long does it last? Is it a new form of chronic fatigue syndrome \u2014 a condition with similar symptoms?<\/p>\n

Or could some symptoms be unrelated to their COVID-19 but a physical reaction to the upheaval of this past pandemic year \u2014 the lockdowns, quarantines, isolation, job losses, racial unrest, political turmoil, not to mention overwhelming illness and deaths?<\/p>\n

These are the questions facing scientists as they search for disease markers, treatments and cures. With $1 billion from Congress, Collins\u2019 agency is designing and soliciting studies that aim to follow at least 20,000 people who\u2019ve had COVID-19.<\/p>\n

\u201cWe\u2019ve never really been faced with a post-infectious condition of this magnitude, so this is unprecedented,\u201d Collins said Monday. \u201cWe don\u2019t have time to waste.\u2019\u2019<\/p>\n

With nearly 30 million U.S. cases of COVID-19 and 119 million worldwide, the impact could be staggering, even if only a small fraction of patients\u00a0develop\u00a0long-term problems.<\/p>\n

Fatigue, shortness of breath, insomnia, trouble thinking\u00a0clearly,\u00a0and depression are among the many reported symptoms. Organ damage, including lung scarring and heart inflammation, have also been seen. Pinpointing whether\u00a0these symptoms\u00a0are directly linked to the virus or perhaps to some preexisting condition is among scientists\u2019 tasks.<\/p>\n

\u201cIs it just a very delayed recovery or is it something even more alarming and something that becomes the new normal?\u201d\u00a0Collins said.<\/p>\n

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\"President<\/div>\n<\/figure>\n<\/div>
President Joe Biden speaks during a visit to the Viral Pathogenesis Laboratory at the National Institutes of Health, Thursday, Feb. 11, 2021, in Bethesda, Md. National Institutes of Health Director Francis Collins, left, and Dr. Anthony Fauci.<\/figcaption><\/figure>\n

There are a few working theories for what might be causing persistent symptoms. One is that the virus remains in the body at undetectable levels yet still causes tissue or organ damage. Or it overstimulates the immune system, keeping it from returning to a normal state. A third theory: Symptoms linger or arise anew when the virus attacks blood vessels, causing minute, undetectable blood clots that can wreak havoc throughout the body.<\/p>\n

Some scientists think each of these may occur in different people.<\/p>\n

Dr. Steven\u00a0Deeks, an infectious disease specialist at the University of California, San Francisco, said researchers first need to create a widely accepted definition of the syndrome. Estimates are\u00a0\u201call over the map because no one is defining it in the same way,\u201d he said.<\/p>\n

Deeks\u00a0is leading one study, collecting blood and saliva samples from volunteers who will be followed for up to two years.<\/p>\n

Some people develop long-term problems even when their initial infections were silent.<\/p>\n

Deeks\u00a0said some evidence suggests that those who initially get sicker from a coronavirus infection might be more prone to persistent symptoms, and women seem to develop them more than men, but those observations need to be confirmed,\u00a0Deeks\u00a0said.<\/p>\n

Van Lear says she was in great shape when she got sick. At 35, the suburban Austin woman had no other health issues and was a busy mother of three who often worked out. First came a chest cold, then a high fever. A flu test came back negative, so her doctor tested for COVID-19. Soon after she developed blinding headaches, debilitating fatigue and nausea so severe that she needed emergency room treatment.<\/p>\n

\u201cI was very scared because no one could tell me what was going to happen to me,\u201d Van Lear said.<\/p>\n

Over the next several months, symptoms would come and\u00a0go:\u00a0burning lungs, a rapid heartbeat, dizzy spells, hand tremors and hair loss. While most have disappeared, she still deals with an occasional racing heartbeat. Heart monitoring, bloodwork and other tests have all been normal.<\/p>\n

Fatigue, fever, and no taste or smell were Karla Jefferies\u2019 first symptoms after testing positive last March. Then came brain fog, insomnia, a nagging smell of something burning that only recently disappeared, and intermittent ringing in her ears. Now she can\u2019t hear out of her left ear.<\/p>\n

Doctors can\u2019t find anything to explain it, and she bristles when some doctors dismiss her symptoms.<\/p>\n

\u201cI understand that COVID is something that we\u2019re all going through together but don\u2019t brush me off,\u201d said Jefferies, 64, a retired state worker in Detroit.<\/p>\n

As an African American woman with diabetes and high blood pressure, she was at high risk for a bad outcome and knows she\u2019s lucky her initial illness wasn\u2019t more serious. But her persistent symptoms and home confinement got her down and depression set in.<\/p>\n

Political and racial unrest that dominated the news didn\u2019t help, and church services \u2014 often her salvation \u2014 were suspended. She knows all that could have contributed to her ill health and says listening to music \u2014 R&B, jazz and a little country \u2014 has helped her cope.<\/p>\n

Still, Jefferies wants to know what role the virus has played.<\/p>\n

\u201cI\u2019m a year in, and to still from time to time have lingering effects, I just don\u2019t understand\u00a0that,\u201d Jefferies said.<\/p>\n

Jefferies and Van Lear are members of Survivor Corps, one of several online support groups created during the pandemic and that have amassed thousands of members. Some are enrolling in studies to help speed the science.<\/p>\n

Dr. Michael Sneller is leading one study at the NIH. So far, 200 have enrolled; they include survivors and a healthy comparison group.<\/p>\n

They are being given a series of physical and mental tests once or twice a year for three years. Other tests are seeking signs of ongoing inflammation, abnormal antibodies and blood vessel damage.<\/p>\n

Sneller said he\u2019s found no serious heart or lung tissue damage so far. He notes that many viruses can cause mild heart inflammation, even some cold viruses. Many people recover but in severe cases the condition can lead to heart failure.<\/p>\n

Fatigue is the most common symptom in the coronavirus group, and so\u00a0far,\u00a0researchers have found no medical explanation for it. Insomnia is common, too \u2014 in both groups.<\/p>\n

Sneller says that\u2019s not surprising.<\/p>\n

\u201cThe whole pandemic and lockdown affected all of us,\u201d he said. \u201cThere\u2019s a lot of anxiety in the control group too.\u201d<\/p>\n

Many have symptoms\u00a0similar to\u00a0those of\u00a0chronic disease\u00a0syndrome;\u00a0and to a condition involving fatigue and thinking difficulties that can develop after treatment for Lyme disease, a bacterial infection spread by certain ticks.<\/p>\n

Researchers are hopeful that studies of long-term COVID-19 may yield answers to what causes those conditions, too.<\/p>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

VOA \u2014 There was no reason to celebrate on Rachel Van Lear\u2019s anniversary. The same day a global pandemic was declared, she developed symptoms of COVID-19. A year later, she is still waiting for them to disappear. And for experts to come up with some answers. The Texas woman is one of thousands of self-described […]<\/p>\n","protected":false},"author":1,"featured_media":93611,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[16],"tags":[],"class_list":["post-93610","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-recposts"],"translation":{"provider":"WPGlobus","version":"3.0.2","language":"en","enabled_languages":["fa","en"],"languages":{"fa":{"title":true,"content":false,"excerpt":false},"en":{"title":true,"content":true,"excerpt":false}}},"_links":{"self":[{"href":"https:\/\/PERSIAN-HERITAGE.COM\/en\/wp-json\/wp\/v2\/posts\/93610","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/PERSIAN-HERITAGE.COM\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/PERSIAN-HERITAGE.COM\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/PERSIAN-HERITAGE.COM\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/PERSIAN-HERITAGE.COM\/en\/wp-json\/wp\/v2\/comments?post=93610"}],"version-history":[{"count":2,"href":"https:\/\/PERSIAN-HERITAGE.COM\/en\/wp-json\/wp\/v2\/posts\/93610\/revisions"}],"predecessor-version":[{"id":93613,"href":"https:\/\/PERSIAN-HERITAGE.COM\/en\/wp-json\/wp\/v2\/posts\/93610\/revisions\/93613"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/PERSIAN-HERITAGE.COM\/en\/wp-json\/wp\/v2\/media\/93611"}],"wp:attachment":[{"href":"https:\/\/PERSIAN-HERITAGE.COM\/en\/wp-json\/wp\/v2\/media?parent=93610"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/PERSIAN-HERITAGE.COM\/en\/wp-json\/wp\/v2\/categories?post=93610"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/PERSIAN-HERITAGE.COM\/en\/wp-json\/wp\/v2\/tags?post=93610"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}